Clinical Trials

Rothman Institute has a world-class research facility and department whose focus is to improve patient care through evidence-based research.  The staff of 36 works everyday on clinical trials, investigator-initiated studies, and database research utilizing a database which contains data from over a million patients.  This database has been developed for over a decade and is a powerful tool that the Rothman Institute has over other Orthopaedic groups in the area and the nation.  We use this data to develop targeted-research studies and clinical trials with a focus on Joint, Spine, Shoulder, Sports, Foot and Ankle, Hand, Trauma, Orthopaedic Oncology, and Infection studies.  These studies are all designed to help improve treatment, infection prevention, and recovery.

Evaluating Bactisure Wound Lavage in Orthopedic Wounds

June 15, 2017

Condition: Infection of Total Knee Joint Prosthesis
Intervention: Device: Bactisure
Sponsor: Zimmer Biomet
Not yet recruiting - verified May 2017

More at ClinicalTrials.gov

A Prospective, Randomized, Comparative Study to Assess the Prevention of Surgical Site Infection (SSI's) in Revision Total Joint Arthroplasty Patients Treated With Single-Use Negative Pressure Wound Therapy (PICO) or Standard Care Dressings (AQUACEL Ag SURGICAL Dressing).

June 06, 2017

Condition: Surgical Incision
Interventions: Device: PICO; Device: Aquacel
Sponsor: Rothman Institute Orthopaedics
Enrolling by invitation - verified June 2017

More at ClinicalTrials.gov

Clinical Evaluation of Integra(R) Cadence(TM) Total Ankle System in Primary Ankle Joint Replacement (CADENCE)

May 02, 2017

Conditions: Rheumatoid Arthritis; Degenerative Arthritis; Post Traumatic Arthritis
Intervention: Device: Integra Cadence Total Ankle Sysyem
Sponsor: Integra LifeSciences Corporation
Recruiting - verified May 2017

More at ClinicalTrials.gov

CLARIX(TM) 100 & CLARIX CORD 1K for Discectomy Patients

April 06, 2017

Condition: Protruded Disk
Interventions: Biological: CLARIX(TM)100; Biological: CLARIX CORD 1K
Sponsor: Amniox Medical, Inc.
Recruiting - verified April 2017

More at ClinicalTrials.gov

The Effect of Patient Education on Opioid Consumption

April 04, 2017

Condition: Rotator Cuff Injury
Intervention: Other: Formal education regarding opioid usage
Sponsor: Rothman Institute Orthopaedics
Completed - verified April 2017

More at ClinicalTrials.gov

Post-Market Study of Robotic-Arm Assisted Total Knee Arthroplasty

February 07, 2017

Condition: Osteoarthritis, Knee
Interventions: Device: Total Knee Arthroplasty using Manual Instrumentation; Device: Total Knee Arthroplasty using Robotic Arm
Sponsors: Rothman Institute Orthopaedics; Stryker Orthopaedics
Enrolling by invitation - verified February 2017

More at ClinicalTrials.gov

Assessing Superion Clinical Endpoints vs. Decompression

January 25, 2017

Condition: Spinal Stenosis, Lumbar Region With Neurogenic Claudication
Interventions: Device: Superion(R) IDS; Procedure: Direct decompression Surgery
Sponsor: VertiFlex, Incorporated
Recruiting - verified June 2017

More at ClinicalTrials.gov

Opioid Use Disorder in the Emergency Department: CTN 0069

January 10, 2017

Condition: Opioid Use Disorder
Interventions: Other: Standard Dissemination Practice; Other: Implementation Facilitation (IF)
Sponsors: Yale University; National Institute on Drug Abuse (NIDA); The EMMES Corporation
Recruiting - verified January 2017

More at ClinicalTrials.gov

Bacterial Colonization With and Without Iodophor-impregnated Adhesive Drapes in Hip Surgery: a Prospective, Randomized Trial

September 27, 2016

Condition: Surgical Wound Infection
Interventions: Device: iodophor-impregnated adhesive drapes; Other: No adhesive drapes
Sponsor: Rothman Institute Orthopaedics
Completed - verified September 2016

More at ClinicalTrials.gov

Home PT vs FORCE PT

September 15, 2016

Condition: Osteoarthritis
Interventions: Other: Home PT via web-based platform; Other: Home PT via paper manual; Other: outpatient PT
Sponsor: Rothman Institute Orthopaedics
Recruiting - verified September 2016

More at ClinicalTrials.gov

Tourniquet vs. no Tourniquet During Total Knee Arthroplasty

September 15, 2016

Condition: Osteoarthritis
Interventions: Other: tourniquet inflated; Other: tourniquet not inflated
Sponsor: Rothman Institute Orthopaedics
Recruiting - verified September 2016

More at ClinicalTrials.gov

Formal vs. Home-Based Physical Therapy After Unicompartmental Knee Arthroplasty

August 22, 2016

Condition: Osteoarthritis
Interventions: Other: Outpatient Physical Therapy; Other: Home Base Physical Therapy
Sponsors: Rush University Medical Center; Rothman Institute Orthopaedics
Recruiting - verified August 2016

More at ClinicalTrials.gov

Comparing Pain Relief Between Exparel(R) Injection vs. On-Q Catheter as the Postsurgical Analgesia Following Total Knee Arthroplasty (TKA)

April 07, 2016

Condition: Osteoarthritis: Joint Replacement Surgery
Interventions: Drug: Exparel; Drug: On-Q pain intra-articular catheter
Sponsor: Rothman Institute Orthopaedics
Completed - verified April 2016

More at ClinicalTrials.gov

Safety and Efficacy of KPI-121 Compared to Placebo in Subjects With Dry Eye Disease

June 28, 2016

Conditions: Dry Eye Syndromes; Keratoconjunctivitis Sicca
Interventions: Drug: KPI-121 0.25% Ophthalmic Suspension; Drug: Vehicle of KPI-121 0.25% Ophthalmic Suspension
Sponsor: Kala Pharmaceuticals, Inc.
Recruiting - verified April 2017

More at ClinicalTrials.gov

Adipose-derived SVF for the Treatment of Knee OA

March 24, 2016

Condition: Osteoarthritis (OA)
Interventions: Device: GID SVF-2; Other: Placebo
Sponsor: The GID Group
Recruiting - verified September 2016

More at ClinicalTrials.gov

One Stage Versus Two Stage For Periprosthetic Hip And Knee Infection

March 23, 2016

Condition: Surgical Site Infection
Interventions: Procedure: One-stage exchange joint replacement surgery; Procedure: Two-stage exchange joint replacement surgery
Sponsors: OrthoCarolina Research Institute, Inc.; The Cleveland Clinic; Hospital for Special Surgery, New York; Rothman Institute at Thomas Jefferson University; Midwest Orthopaedics Rush University Medical Center
Recruiting - verified February 2017

More at ClinicalTrials.gov

Local Intraoperative Analgesic Injection Versus Single Injection Interscalene Nerve Block in Patients Undergoing TSA

February 22, 2016

Condition: Osteoarthritis: Shoulder
Interventions: Procedure: Interscalene brachial plexus block; Procedure: bupivacaine extended-release liposome injection
Sponsor: Rothman Institute Orthopaedics
Completed - verified February 2016

More at ClinicalTrials.gov

PT vs no PT Following THA

February 17, 2016

Condition: Osteoarthritis
Interventions: Procedure: Outpatient physiotherapy; Procedure: Self-guided physiotherapy
Sponsor: Rothman Institute Orthopaedics
Completed - verified March 2016

More at ClinicalTrials.gov

Does Preoperative Administration of Oral Doxycycline Decrease the Colonization Rate of Propionibacterium Acnes in the Dermis of the Shoulder?

February 11, 2016

Condition: Propionibacterium
Intervention: Drug: Doxycycline
Sponsor: Rothman Institute Orthopaedics
Enrolling by invitation - verified February 2016

More at ClinicalTrials.gov

A Comparative Study to Assess the Prevention of Surgical Site Infection (SSI's) in Revision Total Joint Arthroplasty Patients Treated With Single-Use Negative Pressure Wound Therapy (PICO(TM)) or Standard Care Dressings (AQUACEL(R) Ag SURGICAL Dressing)

January 22, 2016

Condition: Surgical Wound Infection
Interventions: Device: Aquacel Ag Surgical Dressing; Device: Single-Use Negative Pressure Wound Therapy (PICO)
Sponsor: Rothman Institute Orthopaedics
Recruiting - verified May 2016

More at ClinicalTrials.gov

Nasal Swab studyComparison of Effectiveness of Povidone-iodine Versus Saline Versus 3M Skin and Nasal Antiseptic 5% Povidone-Iodine USP Swabs for Decolonizing Intranasal MSSA/MRSA

January 06, 2016

Condition: MRSA/ MSSA Colonization of the Nares
Interventions: Drug: Saline; Drug: Povidone-Iodine; Drug: 5% Povidone-Iodine USP swabs
Sponsor: Rothman Institute Orthopaedics
Active, not recruiting - verified January 2016

More at ClinicalTrials.gov

The Use of Barbed Sutures in Total Hip Arthroplasty

November 17, 2015

Condition: Osteoarthritis, Hip
Interventions: Device: Interrupted Knotted Sutures; Device: STRATAFIX Symmetric PDS PLUS Knotless Tissue Control Devices
Sponsors: Rothman Institute Orthopaedics; Ethicon, Inc.
Enrolling by invitation - verified May 2017

More at ClinicalTrials.gov

Comparative Study of Anterior vs. Posterior Surgical Treatment for Lumbar Isthmic Spondylolisthesis

September 29, 2015

Condition: Isthmic Spondylolisthesis
Interventions: Procedure: Anterior Lumbar Interbody Fusion (ALIF); Procedure: Posterior Fusion
Sponsor: AOSpine North America Research Network
Recruiting - verified May 2017

More at ClinicalTrials.gov

Nivolumab After Surgery and Chemotherapy in Treating Patients With Stage IB-IIIA Non-small Cell Lung Cancer

November 03, 2015

Conditions: Stage IB Non-Small Cell Lung Carcinoma; Stage II Non-Small Cell Lung Cancer; Stage IIA Non-Small Cell Lung Carcinoma; Stage IIB Non-Small Cell Lung Carcinoma; Stage IIIA Non-Small Cell Lung Cancer
Interventions: Other: Laboratory Biomarker Analysis; Biological: Nivolumab
Sponsor: National Cancer Institute (NCI)
Recruiting - verified May 2017

More at ClinicalTrials.gov

Triathlon Tritanium Cone Augments Outcomes Study

July 31, 2015

Conditions: Arthroplasty; Replacement; Knee
Intervention: Device: Triathlon Tritanium Cone Augments
Sponsor: Stryker Orthopaedics
Recruiting - verified May 2017

More at ClinicalTrials.gov

A Study of Nivolumab in Advanced Non-Small Cell Lung Cancer (NSCLC)

October 09, 2015

Condition: Non-Small Cell Lung Cancer
Interventions: Drug: Nivolumab; Drug: Bevacizumab; Drug: Pemetrexed; Other: Best Supportive Care; Drug: nab-Paclitaxel; Drug: Paclitaxel; Drug: Docetaxel; Drug: Gemcitabine; Drug: Erlotinib; Drug: Crizotinib; Drug: Carboplatin
Sponsor: Bristol-Myers Squibb
Recruiting - verified June 2017

More at ClinicalTrials.gov

Viscosupplementation in the Hip Following Hip Arthroscopy

June 17, 2015

Condition: Osteoarthritis
Intervention: Drug: Monovisc
Sponsors: Rothman Institute Orthopaedics; Sean McMillan, DO
Unknown status - verified June 2015

More at ClinicalTrials.gov

A Pivotal Study to Assess the InSpace(TM) Device for Treatment of Full Thickness Massive Rotator Cuff Tears

July 01, 2015

Condition: Rotator Cuff Syndrome
Interventions: Device: InSpace sub-acromial tissue spacer system; Procedure: Partial repair of rotator cuff
Sponsor: OrthoSpace Ltd.
Recruiting - verified January 2017

More at ClinicalTrials.gov

Clinical Outcomes Study of the Nexel Total Elbow

June 08, 2015

Conditions: Elbow Joint Destruction; Post-traumatic Lesions; Ankylosed Joints; Advanced Rheumatoid Arthritis; Joint Instability or Loss of Motion; Acute Comminuted Articular Fracture of Elbow Joint Surfaces; Bone Loss Contributing to Elbow Instability; Bilateral Ankylosis From Causes Other Than Active Sepsis; Post-traumatic, or Degenerative Arthritis With Incapacitating Pain
Intervention: Device: Nexel Total Elbow
Sponsor: Zimmer Biomet
Recruiting - verified January 2017

More at ClinicalTrials.gov

Study to Assess Safety and Clinical Activity of Local MBN-101 in Treatment of Infected Osteosynthesis Sites

April 28, 2015

Condition: Bacterial Infection
Interventions: Drug: MBN-101; Other: Placebo
Sponsors: Microbion Corporation; University of Pennsylvania; University of California, San Francisco; Medpace, Inc.; Congressionally Directed Medical Research Programs
Recruiting - verified February 2017

More at ClinicalTrials.gov

DePuy Global Unite Shoulder System

April 06, 2015

Condition: Osteoarthritis
Intervention: Procedure: Total Shoulder Arthroplasty
Sponsor: Rothman Institute Orthopaedics
Enrolling by invitation - verified April 2015

More at ClinicalTrials.gov

Tissue Repository and Master Database for Concussion Biomarker and Risk Calculator Development

March 25, 2015

Condition: Brain Concussion
Intervention: Other: Concussion
Sponsors: Thomas Jefferson University; Rothman Institute Orthopaedics
Recruiting - verified August 2015

More at ClinicalTrials.gov

NCI-MATCH: Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma

June 03, 2015

Conditions: Advanced Malignant Solid Neoplasm; Lymphoma; Recurrent Malignant Solid Neoplasm; Recurrent Plasma Cell Myeloma; Refractory Malignant Neoplasm; Refractory Plasma Cell Myeloma
Interventions: Drug: Afatinib; Drug: Akt inhibitor AZD5363; Drug: Binimetinib; Drug: Crizotinib; Other: Cytology Specimen Collection Procedure; Drug: Dabrafenib; Drug: Dasatinib; Drug: Defactinib; Drug: FGFR Inhibitor AZD4547; Other: Laboratory Biomarker Analysis; Biological: Nivolumab; Drug: Osimertinib; Drug: Palbociclib; Biological: Pertuzumab; Drug: PI3K-beta Inhibitor GSK2636771; Drug: Sapanisertib; Drug: Sunitinib Malate; Drug: Taselisib; Drug: Trametinib; Biological: Trastuzumab Emtansine; Drug: Trk Inhibitor LOXO-101; Drug: Vismodegib; Drug: WEE1 Inhibitor AZD1775
Sponsor: National Cancer Institute (NCI)
Recruiting - verified May 2017

More at ClinicalTrials.gov

Vitamin Therapy in Concussion Management: A Randomized Control Trial

March 03, 2015

Condition: Concussion
Interventions: Dietary Supplement: Experimental: Vitamin Mixture; Dietary Supplement: Placebo
Sponsors: Thomas Jefferson University; Rothman Institute Orthopaedics
Active, not recruiting - verified January 2016

More at ClinicalTrials.gov

LEGION(TM) Revision Metal Hypersensitivity Study

March 05, 2015

Condition: Total Knee Replacement Revision
Interventions: Device: LEGION OXINIUM; Device: LEGION Cobalt Chrome
Sponsor: Smith & Nephew, Inc.
Withdrawn - verified March 2016

More at ClinicalTrials.gov

Safety and Efficacy of SA4Ag Vaccine in Adults Having Elective Open Posterior Spinal Fusion Procedures With Multilevel Instrumentation

March 09, 2015

Condition: Staphylococcal Vaccine
Interventions: Biological: Staphylococcus aureus 4-Antigen (SA4Ag) Vaccine; Other: Placebo
Sponsor: Pfizer
Recruiting - verified June 2017

More at ClinicalTrials.gov

Safety and Efficacy of Levomilnacipran ER in Adolescent Patients With Major Depressive Disorder

April 28, 2015

Condition: Major Depressive Disorder
Interventions: Drug: Placebo; Drug: Levomilnacipran ER; Drug: Fluoxetine
Sponsor: Forest Laboratories
Recruiting - verified May 2017

More at ClinicalTrials.gov

Ascension PyroCarbon Radial Head Study

November 04, 2014

Conditions: Degenerative Arthritis; Radial Head Fracture; Rheumatoid Arthritis
Interventions: Device: Carbon Modular Radial Head replacement; Device: Metal Radial Head replacement
Sponsor: Integra LifeSciences Corporation
Active, not recruiting - verified March 2016

More at ClinicalTrials.gov

A Randomized, Study to Evaluate the Iovera? Device in Treating Pain Associated With Total Knee Arthroplasty

November 03, 2014

Condition: Arthritis of the Knee
Interventions: Device: iovera?; Device: iovera? Sham
Sponsor: MyoScience, Inc
Active, not recruiting - verified April 2016

More at ClinicalTrials.gov

The Influence Of a Natural Anti-Inflammatory Product On Levels Of Inflammatory Markers In Cases With Osteoarthritis Of Knee

October 06, 2014

Condition: Osteoarthritis
Interventions: Dietary Supplement: PRN Joint Health Formula; Dietary Supplement: placebo; Dietary Supplement: PRN Flex Omega Benefits(R) combination
Sponsors: Physician Recommended Nutriceuticals; Rothman Institute Orthopedics
Active, not recruiting - verified August 2016

More at ClinicalTrials.gov

Physical Therapy Prior to Total Knee Replacement

October 06, 2014

Condition: Osteoarthritis of the Hip
Intervention: Behavioral: Supervised physical therapy program prior to total knee replacement surgery
Sponsor: Rothman Institute Orthopaedics
Unknown status - verified October 2014

More at ClinicalTrials.gov

A Prospective, Randomized Trial Comparing Same Day Discharge and Overnight Hospital Stay Among Total Hip Arthroplasties Done by the Direct Anterior Approach

August 29, 2014

Condition: Osteoarthritis of the Hip
Interventions: Procedure: Same day discharge; Procedure: Next day discharge
Sponsors: Rothman Institute Orthopaedics; The Anderson Orthopaedic Clinic
Completed - verified October 2015

More at ClinicalTrials.gov

Trial of Feedback on Blood Use

September 03, 2014

Condition: Compliance With Restrictive RBC Transfusion Guideline
Intervention: Behavioral: Feedback
Sponsor: Brigham and Women's Hospital
Recruiting - verified July 2015

More at ClinicalTrials.gov

A Prospective Study of Instrumented, Posterolateral Lumbar Fusions (PLF) With OsteoAMP(R)

August 22, 2014

Conditions: Spondylolisthesis; Scoliosis; Intervertebral Disc Disease
Intervention: Other: OsteoAMP
Sponsors: Bioventus LLC; West Virginia University; Rush University Medical Center; University of Kansas
Active, not recruiting - verified April 2017

More at ClinicalTrials.gov

TITAN(TM) Reverse Shoulder System

July 21, 2014

Condition: Osteoarthritis of the Shoulder
Intervention: Device: TITAN(TM) Reverse Shoulder System (TRS)
Sponsor: Integra LifeSciences Corporation
Recruiting - verified October 2016

More at ClinicalTrials.gov

Cellentra Viable Cell Bone Matrix (VCBM) Anterior Cervical Discectomy and Fusion Outcomes Study (VCBM/MaxAn)

July 02, 2014

Condition: Cervical Disc Degenerative Disorder
Intervention: Biological: Cellentra VCBM
Sponsor: Zimmer Biomet
Active, not recruiting - verified October 2015

More at ClinicalTrials.gov

Clinical Utility of Rapid CT/NG Testing in the ED

July 23, 2014

Condition: Sexually Transmitted Diseases
Intervention: Other: Rapid Testing
Sponsors: Johns Hopkins University; National Institute for Biomedical Imaging and Bioengineering (NIBIB)
Completed - verified May 2016

More at ClinicalTrials.gov

Triathlon Tritanium Knee Outcomes Study

June 02, 2014

Condition: Arthroplasty, Replacement, Knee
Interventions: Device: Triathlon Tritanium Knee; Device: Triathlon Knee
Sponsor: Stryker Orthopaedics
Active, not recruiting - verified February 2017

More at ClinicalTrials.gov

Genetic Testing in Screening Patients With Stage IB-IIIA Non-Small Cell Lung Cancer That Has Been or Will Be Removed by Surgery (The ALCHEMIST Screening Trial)

July 16, 2014

Conditions: Large Cell Lung Carcinoma; Lung Adenocarcinoma; Stage IB Non-Small Cell Lung Carcinoma; Stage IB Squamous Cell Lung Carcinoma; Stage IIA Non-Small Cell Lung Carcinoma; Stage IIA Squamous Cell Lung Carcinoma; Stage IIB Non-Small Cell Lung Carcinoma; Stage IIB Squamous Cell Lung Carcinoma; Stage IIIA Non-Small Cell Lung Cancer; Stage IIIA Squamous Cell Lung Carcinoma
Interventions: Other: Cytology Specimen Collection Procedure; Other: Laboratory Biomarker Analysis
Sponsor: National Cancer Institute (NCI)
Recruiting - verified June 2017

More at ClinicalTrials.gov

Crizotinib in Treating Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been Removed by Surgery and ALK Fusion Mutations (An ALCHEMIST Treatment Trial)

July 21, 2014

Conditions: Stage IB Non-Small Cell Lung Carcinoma; Stage IIA Non-Small Cell Lung Carcinoma; Stage IIB Non-Small Cell Lung Carcinoma; Stage IIIA Non-Small Cell Lung Cancer
Interventions: Drug: Crizotinib; Other: Laboratory Biomarker Analysis; Other: Placebo
Sponsors: ECOG-ACRIN Cancer Research Group; National Cancer Institute (NCI)
Recruiting - verified March 2016

More at ClinicalTrials.gov

Comparison of Two Periarticular Injection Medications for Adjunctive Pain Management Following Total Knee Arthroplasty (TKA)

February 10, 2014

Condition: Total Knee Arthroplasty
Interventions: Drug: Exparel; Drug: Marcaine
Sponsor: Rothman Institute Orthopaedics
Unknown status - verified February 2014

More at ClinicalTrials.gov

Effects of Tranexamic Acid on Blood Loss and Transfusion Requirement Following Hip Fracture

February 10, 2014

Condition: Hip Fracture
Interventions: Drug: Control: Saline; Drug: Tranexamic Acid
Sponsor: Rothman Institute Orthopaedics
Recruiting - verified April 2016

More at ClinicalTrials.gov

MIS ReFRESH: Robotic vs. Freehand Minimally Invasive Spinal Surgeries

February 05, 2014

Conditions: Degenerative Spine Disease; Spondylolisthesis; Spondylosis
Intervention:
Sponsor: Mazor Robotics
Recruiting - verified October 2016

More at ClinicalTrials.gov

Tornier Shoulder Outcomes Study to Examine Safety and Functional Outcomes in Shoulder Arthroplasty and Fracture Patients

January 24, 2014

Condition: Shoulder Arthroplasty and Fracture Repair
Intervention:
Sponsor: Tornier, Inc.
Recruiting - verified March 2017

More at ClinicalTrials.gov

Zimmer Trabecular Metal Total Ankle

January 14, 2014

Conditions: Degenerative Arthritis; Rheumatoid Arthritis; Post Traumatic Arthritis
Intervention: Device: Zimmer Trabecular Metal Total Ankle System
Sponsor: Zimmer Biomet
Active, not recruiting - verified June 2017

More at ClinicalTrials.gov

Cervical Spondylotic Myelopathy Surgical Trial

February 26, 2014

Condition: Cervical Spondylosis With Myelopathy
Interventions: Procedure: Ventral (Front) decompression with Fusion; Procedure: Dorsal (Back) Decompression with Fusion; Procedure: Dorsal (back) Laminoplasty
Sponsors: Lahey Clinic; Patient-Centered Outcomes Research Institute
Recruiting - verified December 2016

More at ClinicalTrials.gov

Corneal Cross-Linking Comparing Variables

March 20, 2014

Condition: Unstable Corneas
Interventions: Drug: Epithelium-On Riboflavin; Drug: Epithelium-Off Riboflavin; Device: UV Light - Continuous Beam; Device: UV Pulsed Beam
Sponsor: Crowd Health Research, LTD
Unknown status - verified March 2014

More at ClinicalTrials.gov

Outcomes Following Delta Xtend Reverse Shoulder System

December 12, 2013

Condition: Reverse Total Shoulder Arthroplasty
Intervention: Device: DePuy Delta Xtend Reverse TSA
Sponsor: Rothman Institute Orthopaedics
Enrolling by invitation - verified December 2013

More at ClinicalTrials.gov

NOVOCART(R)3D for Treatment of Articular Cartilage of the Knee

September 17, 2013

Condition: Articular Cartilage of the Femoral Condyle Between 2-6cm2
Interventions: Procedure: microfracture; Biological: NOVOCART 3D
Sponsor: Aesculap Biologics, LLC
Recruiting - verified November 2016

More at ClinicalTrials.gov

Post-Approval Clinical Trial of the PCM(R) Cervical Disc

July 18, 2013

Conditions: Radiculopathy; Myelopathy
Interventions: Device: PCM Cervical Disc; Device: Anterior Cervical Discectomy and Fusion (ACDF)
Sponsor: NuVasive
Completed - verified May 2015

More at ClinicalTrials.gov

Pediatric Open-Label Extension Study

July 30, 2013

Conditions: Schizophrenia; Autism; Bipolar Depression
Intervention: Drug: Lurasidone 20, 40, 60, 80 mg, flexibly dosed
Sponsor: Sunovion
Active, not recruiting - verified May 2017

More at ClinicalTrials.gov

Zimmer POLAR - Total Knee Arthroplasty (TKA)

May 16, 2013

Conditions: Osteoarthritis; RheumatoId Arthritis; Traumatic Arthritis; Polyarthritis
Intervention: Device: Zimmer Persona Total Knee System
Sponsor: Zimmer Biomet
Active, not recruiting - verified February 2016

More at ClinicalTrials.gov

PARADIGHM A Natural History Registry for Patients With Chronic Hypoparathyroidism

August 01, 2013

Condition: Chronic Hypoparathyroidism
Intervention: Other: None [Natural history registry]
Sponsor: Shire
Recruiting - verified May 2017

More at ClinicalTrials.gov

Botulinum Toxin A to Treat Flexion Contracture After Total Knee Arthroplasty

April 08, 2013

Condition: Flexion Contracture Following Total Knee Replacement
Interventions: Drug: Botox; Drug: placebo
Sponsors: Rothman Institute Orthopaedics; Sharpe-Strumia Research Foundation
Unknown status - verified December 2013

More at ClinicalTrials.gov

Arthrex Eclipse(TM) Shoulder Prosthesis

February 11, 2013

Condition: Osteoarthritis
Interventions: Device: Univers(TM); Device: Eclipse(TM) Total Shoulder Replacement
Sponsor: Arthrex, Inc.
Recruiting - verified May 2017

More at ClinicalTrials.gov

Oral Antibiotics After 2-Stage Revision for Infected Total Hip Arthroplasty and Total Knee Arthroplasty

January 02, 2013

Condition: Prosthesis-Related Infections
Intervention: Other: Oral Antibiotics
Sponsor: Rush University Medical Center
Recruiting - verified March 2017

More at ClinicalTrials.gov

Treatment of Plantar Fasciitis With Xeomin

August 30, 2012

Condition: Plantar Fascitis
Intervention: Drug: Xeomin
Sponsors: Rothman Institute Orthopaedics; Merz Pharmaceuticals, LLC
Completed - verified January 2017

More at ClinicalTrials.gov

Active Surveillance Post-Approval Atudy of the Stelkast Surpass Acetabular System

August 21, 2012

Condition: Survivorship and Long-term Safety and Effectiveness of the Stelkast Surpass Acetabular System
Intervention: Device: Stelkast Surpass Acetabular System implant
Sponsor: StelKast, Inc.
Terminated - verified October 2016

More at ClinicalTrials.gov

Evaluation of Subchondroplasty(TM) for Defects Associated With Bone Marrow Lesions

June 14, 2012

Condition: Bone Marrow Edema
Intervention: Procedure: Subchondroplasty
Sponsor: Zimmer Biomet
Recruiting - verified January 2017

More at ClinicalTrials.gov

Total Hip Arthroplasty Using Small Direct Anterior Incision: The Role of Short Femoral Stem

June 04, 2012

Condition: Total Hip Arthroplasty
Intervention: Procedure: Total Hip Arthoplasty
Sponsor: Rothman Institute Orthopaedics
Unknown status - verified April 2013

More at ClinicalTrials.gov

A Brief Intervention

June 28, 2012

Conditions: Dating Violence; Dating Abuse
Intervention: Behavioral: Brief, motivational interview and one booster session
Sponsors: Boston University; National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Completed - verified March 2017

More at ClinicalTrials.gov

Medium Term Survivorship of Cementless THA Performed Using the Bone Preservation Tri-Lock Femoral Stem

February 24, 2012

Condition: Total Hip Arthroplasty
Intervention: Procedure: Total Hip Arthroplasty
Sponsor: Rothman Institute Orthopaedics
Unknown status - verified February 2014

More at ClinicalTrials.gov

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